Abstract
SYNTHESIS, AND BIOLOGICAL EVALUATION OF NEW PYRIMIDINE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS

Raviteja Bandla*, Prasada Rao Manchineni, A. Ramanjaneyulu, K. Rasi, K. Lokeswari, K. Venkata Hari Priya, V. Anjali

ABSTRACT

Pyrimidine is the parent substance of a large group of heterocyclic compounds and plays a vital role in many biological processes, as found in nucleic acids, several vitamins, co-enzymes and purines. keeping this in mind new pyrimidines are synthesised by conventional method and the structures were confirmed by spectral evidence. synthesised compounds were screened for their antimicrobial activity. Compound B7P7 and B8P8 possessed maximum activity and this may be due to the presence of two electron withdrawing groups.

Keywords: Pyrimidine, phenylhydrazine and antimicrobial activity.


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