Abstract
HISTOPATHOLOGICAL AND BIOCHEMICAL CHANGES IN GRASS CARP GILL AND MUSCLE TISSUES DUE TO NICKEL EXPOSURE MAY BE RELATED TO THE INDUCTION OF OXIDATIVE STRESS

Kalist Shagirtha, Priya, Arthi, Arun and Milton Prabu*

ABSTRACT

The present study was designed to investigate the Nickel (Ni) induced biochemical and histopathological changes in gill and muscle tissues of fresh water fish grass carp. These Fish were exposed to 35mg/L of Nickel sulphate for 7 And 14 days. The activity of lipid peroxidation markers, antioxidant defense system, total protein, lipids, estimation of glucose and glycogen were assayed in Gill. Fish exposed to nickel for 7 and 14 days a significant (p < 0.05) increase in the levels of LPO along with significant (p < 0.05) decrease in the levels of SOD, GSH and GPx and siginificant (p < 0.05) decrease in the level of total protein, lipids, glucose and glycogen. These results indicate that 14 days Ni exposed fish were increase in the level of LPO along with decrease in the level of SOD, GSH, GPx, protein, lipids, glucose and glycogen when compared to 7 days Ni exposed fishes. The histopathological studies in the gill and muscle tissues of fish also supported the view that sub lethal dose of Nickel for 14 days significantly increased the morphological alterations when compared with 7 days Ni exposed fish. Our results clearly suggest that even at a very low sub lethal dose of Nickel exposure to grass carp for 7&14 days increased the level of metabolic stress, oxidative stress, antioxidant depletion and morphological alterations in the selected tissues.

Keywords: Nickel, Oxidative stress, Antioxidants, Lipid peroxidation, Gill.


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