Abstract
TO COMPARE THE EFFICACY AND SAFETY OF GABAPENTIN AND PREGABALIN FOR PERIPHERAL NEUROPATHY IN TYPE 2 DIABETIC PATIENTS

Dr. Sumit Kumar*, Dr. Prithpal Singh Matreja and Dr. Jigar Haria

ABSTRACT

Diabetic neuropathies are nerve damaging disorders and occurs in ~ 50% of individuals with long – standing type 1 and type 2 Diabetes Mellitus. Clinical features of diabetic neuropathy are mild tingling sensation in one or two of the toes in some case and in other cases, patients may be affected with severe pain and numbness in foot, sensory loss and dysesthesia. There are very less studies done in this field and no pattern of efficacious drugs is set in literature, although drugs are used to give symptomatic relief and to decrease the progress of disease but their ADR profile is also not clearly understood. Keeping these problem in mind, study was planned to evaluate efficacy and safety of Gabapentin & Pregabalin in Diabetic neuropathic patients. Total 60 patients were enrolled in the study. Neuropathy Symptom Score (NSS) & Neuropathy Deficit Score (NDS) were used to evaluate efficacy at 0, 30 and 90 days of treatment. ADRs were noted for monitoring safety at 30 and 90 days of treatment. Mean Difference of Gabapentin was more than Pregabalin after applying NSS & NDS. While Mean ADR Score was less in Gabapentin compare to pregabalin. P-value was significant after comparing both drugs. Gabapentin was more efficacious than Pregabalin after evaluating NSS and NDS value. More number of ADR were seen in Pregabalin compared to Gabapentin. Hence Gabapentin was more efficacious and safer drug for Diabetic neuropathy.

Keywords: Diabetic Neuropathy, Neuropathy Symptom Score, Neuropathy Deficit Score.


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