Abstract
DIFFERENT POLYMERS UESD TO DESIGN AND EVALUATION OF CONROLLED RELEASE MATRIX TABLETS OF ACECLOFENAC

M. Harish Reddy*, Md. Qutub Uddin, Adnan Al Shaik, Mariyam Sultana, Shibani Fatima and Rizwana Hashmi

ABSTRACT

Aceclofenac is a Non-steroidal anti inflammatory drug (NSAID) used to the anti-inflammatory effects of aceclofenac have been shown in both acute and chronic inflammation. Controlled release matrix tablets of Aceclofenac were prepared by using three polymers, one of the hydrophilic polymer hydroxy propyl methyl cellulose K15M (HPMCK15M), carbapol-934 and Xanthan gum with four concentrations (drug: polymer ratios-1:1, 1:2, 1:3, 1:4), by wet granulation method. The granules were evaluated for bulk density, tapered density, bulkiness, angle of repose, Hausners ratio and compressibility index. In vitro release studies revealed that Aceclofenac formulation with high proportion of HPMCK15M (1:1) was able to control the drug release for 12 hours (85.41.26). The in-vitro drug release data, curve-fitting kinetic analysis[9] and all the formulations followed the mechanism of erosion and diffusion.[19] All the formulations were subjected to stability analysis for stored at 452C, 755RH up to 45 days.

Keywords: Controlled release, HPMC K15M, carbapol-934, Xanthan gum, wet granulation, Hydrophilic polymer, NSAID.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • MAY ISSUE PUBLISHED

    MAY 2018 Issue has been successfully launched on 1 May 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT