Abstract
SCREENING OF BIOLOGICAL ACTIVITIES OF ACACIA FARNESIANA (GUYABABLA), A MEDICINAL PLANT OF BANGLADESH

Tasnuva Sharmin,* and Syeda Nazia Mahazabin

ABSTRACT

The crude methanol extract of bark of Acacia farnesiana (L.) Willd. as well as its hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screening for total phenolic content, and cytotoxic, thrombolytic, membrane stabilizing and antimicrobial activity assays. Among the extractives of A. farnesiana, the hexane soluble fraction showed the highest amount of phenolic content (28.05±0.75 mg of GAE/ g of extractives). In brine shrimp lethality bioassay, the aqueous soluble fraction of crude methanol extract of A. farnesiana revealed the presence of the highest amount of cytotoxic principles (LC50= 0.59±0.32 μg/ml) as compared to 0.45 μg/ml for vincristine sulphate. This fraction also showed the highest ability to promote lysis of human blood clot (45.36±0.26%) as compared to 66.77% clot lysis by standard streptokinase while evaluating the thrombolytic activity of A. farnesiana extractives. At concentration 1.0 mg/ml, the hexane soluble fraction inhibited 63.30±0.33% and 26.39±0.72% of haemolysis of RBCs induced by hypotonic solution and heat as compared to 71.90% and 42.12% by acetyl salicylic acid, respectively. Among the A. farnesiana extractives, only the carbon tetrachloride soluble fraction revealed antimicrobial activity against the test organisms with zone of inhibition ranging from 9.0 to 20.0 mm.

Keywords: Acacia farnesiana (L.) Willd., total phenolic content, cytotoxicity, thrombolytic activity, membrane stabilizing activity, zone of inhibition


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