Abstract
PHYSICOCHEMICAL EVALUATION AND STANDARDIZATION OF THE SIDDHA FORMULATION SAMBIRANI POO KULIGAI IN ACCORDANCE WITH AYUSH REGULATION

M. Vijibala*, R. Karolin Daisy Rani, V. Velpandian and M. Pitchiah Kumar

ABSTRACT

Siddha formulations becomes popular cure as an ailment for treating several diseases throughout the globe, as a complementary and alternate medicine. Physicochemical evaluation of the preparation plays vital role in establishing the monograph of the formulation, as it becomes the documentary evidence to substantiate the standards of the preparation. It renders the useful information like genuinity, stability, selective characteristic feature and nature of the compound’s present in the drug. Siddha also have standardized protocols for purification and detoxification of certain phytocomponents used in specific formulations. As this will greatly reduce the toxicity and also enhance the therapeutic efficacy of the formulation. Through systematic standardization a formulator can profile the preparation with respect to the following (i) Physiochemical parameters (ii) Category of phytocomponents (iii) Nature of individual chemical component (iv) Structural and functional group analysis (v) Correlation of mechanism with respect to the functional group present in bioactive phytocomponents (vi) Drug stability (vii) Pharmacokinetic profiling (viii) Receptors on which the drug acts and ix) Chances of possible interaction. The main aim of the present investigation is to systematically purify, standardize and to carry out the Invitro antioxidant evaluation of the novel siddha preparation Sambirani Poo Kuligai (SPK) as per AYUSH regulations. The organoleptic character of the drug SPK justifies the purity of the formulation. The results obtained from the physicochemical evaluation revels that the total ash value of SPK was 79.62 %, loss on drying value is 13.62% in which water soluble ash value is 16.75% and acid insoluble ash was found to be 0.225% respectively. Phytochemical analysis reveals the presence of phytocomponents such as alkaloids, carbohydrates, glycosides, phytosterol, triterpenes, proteins and amino acids. Biochemical investigation of the test drug SPK reveals the presence of the following radicals such as calcium, magnesium, sodium and phosphate. HPTLC analysis of the SPK reveals the presence of 11 phytocomponents. In conclusion the trial drug SPK confirms the regulatory requirement and also possess significant phytocomponents such as phytosterols which contributes to the beneficial effect on polycystic ovarian syndrome (PCOS).

Keywords: Siddha, Standardization, Physicochemical, Sambirani Poo Kuligai, AYUSH regulations, HPTLC, PCOS.


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