Abstract
PREPARATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF NSAID AND ANTI HISTAMINE DRUG IN COMBINATION

*Deepak Panwar, Sunil Shah, C. K. Tyagi, Neelesh Chaubey and Harish Pandey

ABSTRACT

Tablets are the most widely used dosage form due to its advantages as ease of administration, low cost of manufacturing. Whereas conventional tablets have several disadvantages as they are difficult to swallow by geriatric and pediatric patients which result in poor patient compliance. So to provide medication with more conventional mean there is a desire to formulate Fast dissolving tablets. Also new chemical entry (NCE) discovery and development are time consuming and very much expensive. So pharmaceutical industries focusing on development of a new drug delivery system instead of developing new chemical entry which result in increased bioavailability, less side effects and more convenience for patients. Orally disintegrating tablets (ODTs) are novel technology, there tablets may rapidly undergo disintegration and dissolution into a form of solution without the need of water. Paracetamol is mostly used NSAID‟s drug having both analgesic and antipyretic action also have less anti inflammatory action. It is suitable for both pediatric and geriatric patients; also it is most suitable analgesic for pregnant woman. Levocetirizine Dihydrochloride is a third generation non-sedative antihistaminic which is orally active. It is used mainly for seasonal, perennial allergic rhinitis, hay fever also for chronic idiopathic urticaria. The present work revealed that mouth dissolving tablet of Levocetirizine dihydrochloride and paracetamol with smaller disintegration time, sufficient mechanical strength, were achieved by using proper concentration of superdisintegrants and other excepients. FTIR studies show no shifts in peak of drugs that reveal that there is no interaction between drugs and excepients.

Keywords: ODT, Paracetamol & Levocetirizine Dihydrochloride.


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