Abstract
HAEMATOLOGICAL AND CYTOKINE PARAMETERS IN MALE ALBINO RATS ADMINISTERED ORALLY WITH SINGLE/COMBINED DOSES OF TRAMADOL/VIAGRA

Jacob, Ransom Baribefii,* Eze, Evelyn Mgbeoma. and Jeremiah, Zaccheaus Awortu

ABSTRACT

This study evaluated haematological and cytokine parameters in male albino rats administered orally with single/combined doses of tramadol/viagra. Twenty-two male albino rats (180-220g body weight) were grouped into 4 (n=6) administered orally with tramadol+viagra (6&4mg/220g.bwt), viagra (4mg/180g.bwt), tramadol (6mg/180g.bwt) and control (n=4) for 3weeks. Rats were sacrificed by cardiac puncture and 9ml of blood collected for analysis of haemoglobin concentration (Hb), Packed cell volume (PCV), Red blood cell (RBC) count, White blood cell (WBC) count, platelet count, interleukin 8 (IL-8) and interleukin 10 (IL-10) using Elabscience ELISA-kits. GraphPad Prism 5.03 software was used to analyze data generated. Haematological parameter analysed showed no statistically significant difference in the values for RBC count of the various treatment groups compared with control group (p>0.05). There was however, a statistically significant decrease Hb and PCV values across the various treatment groups compared with control group (p<0.05). A statistically significant increase was seen in WBC count in viagra, tramadol group, whereas a statistically significant decrease WBC was observed in tramadol+viagra group (P<0.05). Cytokine parameters showed no statistically significant difference in IL-8 in sildenafil, tramadol groups (p>0.05), significant decrease in IL-8 value of tramadol+viagra group compared with control (p<0.05). There was no statistically significant difference in IL-10 for tramadol+viagra, sildenafil groups compared with control (p>0.05) but a statistically significant increase was seen in the value of IL-10 for tramadol group (p<0.05). Daily use of single/combine doses of Tramadol, Viagra causes significant alterations in haematological, cytokine parameters. Thus, anaemic, cancer patients should be properly monitored to avoid the risk of aggravating their condition. There is need to evaluate the effects of these drugs on the haematological and cytokines parameters in humans.

Keywords: Tramadol, Viagra, Haematological, Cytokine, interleukin.


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