Abstract
A NOVEL SOLUBILITY ENHANCEMENT METHOD OF LANSOPRAZOLE BY MIXED HYDROTROPY FOR THE FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LANSOPRAZOLE

Pasam Jyothirmayi*, S. Sumathi, V. Yuvaraj, A.Anusha and Ch. Suryakumari

ABSTRACT

Low aqueous solubility is a major problem faced during formulation development of new drug molecules. Lansoprazole (LPZ) is an anti ulcer agent and is a good example of the problems associated with low aqueous solubility. Lansoprazole is practically insoluble in water. Hence, purpose of this research was to enhance the solubility of LPZ by using the concept of mixed hydrotropy. Initially, solubility of LPZ was determined individually in urea sodium acetate, and sodium benzoate at concentration of 10% w/v solutions using purified water as a solvent. Highest solubility was obtained in 10% urea solution. In order to decrease the individual Hydrotrope concentration mixed hydrotropic agents were used. Highest solubility was checked with combination of these hydrotropic agents. The optimized combination was utilized in the preparation of solid dispersions by using distilled water as a solvent. Formulation of Immediate release tablets of Lansoprazole (LPZ) using mixed hydrotrophy technique with different concentrations of super disintegrants such as Crosspovidone, Croscarmellose sodium and sodium starch Glycolate were prepared by using direct compression method. Dissolution studies of prepared tablets were done using USP Type II apparatus. The batch CF3 tablets show 99.0% cumulative drug release within 40 min. There is miraculous enhancement in solubility and bioavailability, hence it was concluded that the concept of mixed hydrotropic solid dispersion is novel, safe and cost-effective technique for enhancing the bioavailability of poorly water-soluble drugs.

Keywords: Lansoprazole, Mixed hydrotropy, Solid dispersions.


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