Abstract
ANTIHYPERTENSIVE AND DIURETIC ACTION OF ADATHODAI ILAI CHOORANAM - A SIDDHA MONO-HERBAL FORMULATION

S. Selvakumar*, S. Visweshwaran, S. Sivakumar, A. Mariappan and S. Ushakanthan

ABSTRACT

Aqueous extract of Adhathodai Ilai Chooranam (Adhathoda vasica leaf powder) was evaluated for its antihypertensive activity in renal artery occluded hypertensive rats. Male Wistar rats (200-250 g) randomly divided into six groups (n = 6) were pretreated with aqueous extract of Adhathodai Ilai Chooranam for 6 weeks. Hypertension was induced in animals by clamping the renal artery with renal bulldog clamp for 4 h. Ischemia of the kidneys causes elevation of blood pressure by activation of the renin-angiotensin system. Elevated blood pressure of the animals was significantly (p <0.O5) decreased by the administration of of ALC at dose levels of 250, 500, 1000mg/Kg i.v. Captopril (angiotensin converter enzyme inhibitor ACE-I at the dose of 1mg/kg showed significant (p <0.O5) reduction in the elevated blood pressure. Also, Adathodai Ilai Chooranam at 500 and 1000 mg/Kg showed significant increase in urine volume as well as sodium and chloride and with mild potassium sparing effect.

Keywords: Adhathodai Ilai Chooranam, Adhathoda vasica, Traditional medicine, Herbal medicine.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • OCTOBER ISSUE PUBLISHED

    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT