Abstract
DEVELOPMENT & VALIDATION OF A STABILITY- INDICATING HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC (HPTLC) METHOD FOR THE ESTIMATION OF ACOTIAMIDE HYDROCHLORIDE HYDRATE

Mrinalini C. Damle* and Antra Sen

ABSTRACT

The objective of the study was to develop & validate a simple, specific, rapid, precise and accurate HPTLC method for the estimation of Acotiamide Hydrochloride. The HPTLC separation was carried out on Merck TLC aluminium sheets Precoated with Silica gel 60F254 using mobile phase as Chloroform : methanol(6:4v/v) and it was validated as per ICH Q2 (R1) guidelines. Forced degradation study was carried out under different stress conditions. The analysis of the spots was performed at 332nm. A linear data over the range of 200-1000ng/band with a good correlation coefficient of 0.996 unfolds linear relationship between area and concentration in calibration curve. Stress degradation study of Acotiamide Hydrochloride was done according to ICH guidelines Q1A (R2) and the proposed method can be used for the routine analysis of Acotiamide Hydrochloride in bulk and pharmaceutical dosage form.

Keywords: Acotiamide Hydrochloride Hydrate, HPTLC, ICH guidelines, forced degradation studies.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • OCTOBER ISSUE PUBLISHED

    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT