Abstract
SYNTHESIS CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SUSBSTITUTED BENZIMIDAZOLES

Syed Shah Abdus Salaam*, Dr. Mohammed Abdul Aleem, Dr. Aliya Parveen, Tahmina Sultana and Mohsina Abid

ABSTRACT

This research work deals with synthesis of benzimidazole and its halogen derivatives that can be potentially developed as Anthelmenthic drugs. Benzimidazole has been synthesized by cyclocondensation reaction between Orthophenylene diamine and formic acid. Considering the antibacterial, antifungal and anthelmenthic properties shown by various benzimidazole derivatives, halogen substituted benzimidazole were prepared by electrophilic substitution of halogen in presence of acetic acid.two bromine derivaties of Benzimidazole have been synthesized. The synthesized derivatives were characterized by various analytical methods and further the anthelmintic activity was performed on Pherithima posthuma and the derivatives shown good anthelmenthic activity. Further the above synthesized derivatives can be studied for identifying the antibacterial, antifungal activites.

Keywords: Benzimidazole, Anthelmenthic, Antibacterial, Antifungal, and Halogen derivaties.


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