Abstract
A NESTED CASE-CONTROL STUDY ON ANTIPSYCHOTIC DRUGS AND RISK OF VENOUS THROMBOEMBOLISM AMONG MENTALLY ILL PATIENTS

*Dr. Sampoornam W., Sindhulakshmi T., Arunadevi K., Sangeetha A., Deepa M., Akila V., Haris Asfaque I., Kowsalya T. and Vennila M.

ABSTRACT

Context: There is an association between use of antipsychotic drugs and risk of venous thromboembolism in a large primary care population. The increased risk was more marked among new users and those prescribed atypical antipsychotic drugs. Aim of the study: To determine association between antipsychotic drugs and risk of venous thromboembolism in nested cases and controls. Methods: After obtaining implied consent, mentally ill cases and controls with & without record of venous thromboembolism between January 2014 and December 2016, who fulfilled the inclusion criteria were enrolled in the study through computerized codes/Medical records patients in Government Head Quarters Hospital at Erode. Each case with venous thromboembolism matched with up-to two controls without venous thromboembolism (50 cases and 100 matched controls) by adapting propensity matching were recruited during April 2017. Incidence density sampling technique was used to recruit the nested cases and controls among mentally ill patients based on the detection of the cases, controls were selected and matched. Results: The computed odds ratio between antipsychotic drugs and risk of venous thromboembolism among nested cases and controls showed statistical significance with current timing of antipsychotic use, both typical & atypical antipsychotics, low and high potency of antipsychotics & oral mode of drug administration. Significant association (2= 5.64) was obtained between risk of venous thromboembolism and diagnosis in controls. Conclusion: Psychiatric nurses should be hyper vigilant to identify the antipsychotic drugs and risk of venous thromboembolism among mentally ill patients in clinical settings.

Keywords: Antipsychotics, Venous Thromboembolism, Nested- Case Control, Mentally Ill.


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