Abstract
EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF OCIMUM SANCTUM (TULSI) LEAF IN WISTAR ALBINO RATS AFTER SUB-ACUTE ADMINISTRATION

Sumina S., Kingshuk Lahon*, Johan Pandian and Manimekalai K.

ABSTRACT

Background: Allopathic antidepressants are ineffective in many patients causing treatment failure and addition of adjuvant and/or substitutions. Moreover, they have adverse effects causing decreased compliance. Hence there is potential for effective herbal alternatives with fewer adverse effects like Ocimum sanctum. Aim: To evaluate the antidepressant activity of ethanolic leaf extract of Ocimum sanctum after subacute administration. Materials and Methods: 24 wistar albino rats of either sex were randomly divided into four groups (n=6) and administered normal saline, Ocimum sanctum ethanolic extract (OSEE), Fluoxetine and OSEE + half dose Fluoxetine respectively for 30 days. Forced swim test (FST) and modified tail suspension test (TST) for depression were performed on days 1, 7, 15 and 30. Results were expressed as Mean ± SEM. One way ANOVA (P<0.05 regarded as significant at 95% C.I.), followed by Tukey’s post hoc test were used for statistical analysis. Results: Animals receiving OSEE and OSEE + half dose Fluoxetine demonstrated significant antidepressant effect by reduction in the duration of immobility in FST and TST on days 7, 15, 30, but not on day 1. The combination showed antidepressant effect which was comparable to that of full dose of fluoxetine. Conclusion: OSEE alone and its combination with half dose standard drug fluoxetine showed significant antidepressant activity with the combination demonstrating activity comparable to that of full dose standard drug on sub-acute administration.

Keywords: Sub-acute, Antidepressant, Ocimum sanctum, Albino Rats.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • OCTOBER ISSUE PUBLISHED

    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT