Abstract
CHANGES IN SERUM VASPIN AND OMENTIN AFTER SLEEVE GASTRECTOMY IN TYPE 2 DIABETIC MODEL

Mohamad Yosof Rezk* and Ebtesam M. Ibrahim

ABSTRACT

Background: Vaspin and Omentin showed different serum levels in diabetes and obesity. Aim: No available data demonstrating the effect of sleeve gastrectomy on Omentin and Vaspin serum levels in a model of diabetic obese rats. Materials and Methods: 32 male albino rats divided into four groups: control (C) group, Diabetic (D), sham operated (SO) and Sleeve Gastrectomy (SG). Serum levels of Vaspin and Omentin, Body Weight, fasting glucose, plasma insulin and HOMA-IR are estimated in all groups and in SO and SG groups at the 2nd, 4th and 12th week after surgery. Results: Omentin increased significantly in diabetic and diabetic sham operated at 2nd, 4th, 12th weeks and diabetic sleeve gastrectomy at 2nd week (p=0.03, p=0.04, p=0.03, p=0.04 and p=0.04 respectively) compared with control group. Insignificant differences were found in diabetic sleeve gastrectomy at 4th and 12th week groups compared with control group. Significant differences are found in sleeve gastrectomy at 4 and 12 weeks (p=0.04 and p=0.009 respectively) compared with the Diabetic group. Significant reduction in Vaspin (V) was found in D group in relation to control group (p=0.0001). Highly significant increases in Vaspin were found in SG group at 2w, 4 w and 12 weeks compared with D group (p< 0.001, 0.0001). Insignificant reductions in BW are found in SG after 2 weeks compared with D group however, significant reductions in body weight were found in SG group at 4th and 12th weeks compared with D group. Highly significant reductions (p< 0.0001) in insulin levels were found between diabetic and sham operated (2, 4 and 12 w) groups compared with control group. No significant differences in insulin level between SG group at 12 w and the control group. Insulin significantly increased in SG group at week 2, 4 and 12 (p<0.01, p< 0.0001 and p< 0.0001 respectively) in comparison with diabetic group. In Conclusion, Sleeve gastrectomy improved serum Omentin and Vaspin levels in obese diabetic rats and returned these levels to values similar to normal control non-diabetic non-obese rats.

Keywords: Omentin; Vaspin; Sleeve gastrectomy; Type 2 diabetes; Obesity.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • OCTOBER ISSUE PUBLISHED

    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT