West, Samuelba Emi, Dr. Davies Tamuno-Emine, Dr. Felix U. Igwe, Owhondah Linus Samuel


Some dietary fats pose negative effect on the human cardiovascular system. These effects over time have been reported to be preventable using plant extracts. Allium sativum have been found to posses many therapeutic effects. The aim of this study is to investigate garlic extraction for their hypolipidemic effect on hyperlipidemia induced by thermally treated palm oil which is a cholesterol rich diet. Twenty adult male wistar albino rats were used in these experiments. The animals were divided into five groups (4 each). Group I, the Control group (CO) where the animals were fed with basal diet. Group II, the Fresh Palm Oil group (FPO), the animals were fed with basal diet containing fresh pure palm oil (10ml/300g diet). Group III, the thermally treated palm oil group (TTPO) where the animals were fed with the basal diet containing thermally treated palm oil at a dose of (10ml/300g of diet). The group (Group IV) were fed with 300g of basal feed and they received 1m each of the garlic extract orally simultaneously. The last group (Group V) received the basal feed and a combination of thermally treated palm oil (10ml/300g diet) and 1ml of Garlic extract. Blood samples were collected via cardiac puncture, sera was separated from clotted samples for biochemical analysis. The data were analysed using analysis of variance (ANOVA) where p 0.05 is considered statically significant. The findings showed that the effects of Basal Feed + Thermally treated palm oil were significant in CHO and LDL at p value of 0.002 and 0.0364 levels respectively. Also, the main effects of Basal Feed + Garlic were respectively significant in on CHO and HDL at .p<0.05 level of significance. The results of Thermally Treated Palm Oil + Garlic were significant in TG and LDL at p<0.05 level of significance. Thus, evidence obtained from this study indicates that garlic extraction has potential effects in the prevention and control of hyperlipidemia complications and is beneficial when taken as a dietary supplement.

Keywords: Allium sativum, hypolipidemic, hyperlipidemia.

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