Abstract
ASSESSMENT OF NEUROBEHAVIOURAL PROPERTY OF ETHANOLIC EXTRACTS OF CULCASIA SCADEN AND ITS EFFECT ON HISTOARCHITECTURE OF TEMPORAL LOBE WISTAR RATS

*Okoronkwo, Samuel Okafor, Egwu, Eni Ogbonnia, Ewunonu, E. O., Eteudo, A. N., Uchewa, Obinna O., Igwe , Chika Emeka , Okekpa Uchenna Oyibe

ABSTRACT

Culcasia scaden is used traditional for the treatment of various disease conditions. This study was carried out to investigate the neurohavioural properties of the ethanolic leaf extract and its effect on the histoarchitecture of the temporal lobe. Twenty adult Wistar rats were used for this research and were randomly divided in four groups A, B, C and D of five animals each. Group A served as negative control and received 1ml of the distilled water, while B and C served as the experimental group and received 100mg/kg and 150mg/kg per body weight of the animal. Group D was the positive control and received 2.5mg/kg of diazepam. The experiment last for 14 days, on the fourtheenth day, behavioual test was carried out using elevated plus maze. After the behavioural test the animal was sacrificed by chloroform inhalation and the brain harvested and fixed in 10% formol saline and tissue was processed using normal histological techniques and the sections were photomicrographed read by a pathologist. The result showed that the ethonolic extract showed neurohavioural property (anxiogenic property) and altered the histoarchitecture of the temporal lobe of the brain. In conclusion the ethanolic leaf extract of Culcasia scaden affected the neurohaviour of Wistar rat and altered the microanatomy of the temporal lobe.

Keywords: Neurobehaviour, Culcasia scaden, Temporal lobe, histoarhitecture Diazepam.


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