Abstract
LIGAND MEDIATED TARGETED DRUG DELIVERY SYSTEM

V. Viswanath*, C. Rajaram, R. Fathima and K. Hanna Pravalika

ABSTRACT

This paper is an overview of advance and prospects in application of nanotechnology for cancer treatment. Cancer is the foremost causes of death worldwide. Passing away from cancer are continuously rising worldwide with a projection of about 12million are passing away from cancer. So, we are using the ligand targeted therapy (LTT). The Most cancer medicines are designed to impede with one or more events in the cell proliferation. As healthy cells may also require to proliferate and circumvent apoptosis, anticancer agents can be toxic to such cells. To diminish these toxicities, strategies have been developed wherein the therapeutic agent is targeted to tumour cells through conjugation to a tumour-cell-specific small-molecule ligand, thereby reducing delivery to normal cells and the associated collateral toxicity. This Review describes the major principles in the design of ligand-targeted drugs and provides an overview of ligand–drug conjugates and ligand–imaging-agent conjugates that are currently in development It is a powerful pharmaceutical strategy to achieve selective drug delivery to pathological cells, for both therapeutic and diagnostic purposes, this active drug targeted approach is based on the discovery that there are receptor overexpressed on pathological cells, compared to their expression in normal tissues. Recent studies high lights the ligand density plays an important role in targeting efficacy. Furthermore, LTT applications in diseases form cancer and those exploiting receptor overexpressed at cytoplasmic level are growing.

Keywords: Cancer, Toxicity, Tumour, Ligand, Liposomes, Receptor mediated targeting.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • OCTOBER ISSUE PUBLISHED

    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT