V. Viswanath*, C. Rajaram, R. Fathima and K. Hanna Pravalika


This paper is an overview of advance and prospects in application of nanotechnology for cancer treatment. Cancer is the foremost causes of death worldwide. Passing away from cancer are continuously rising worldwide with a projection of about 12million are passing away from cancer. So, we are using the ligand targeted therapy (LTT). The Most cancer medicines are designed to impede with one or more events in the cell proliferation. As healthy cells may also require to proliferate and circumvent apoptosis, anticancer agents can be toxic to such cells. To diminish these toxicities, strategies have been developed wherein the therapeutic agent is targeted to tumour cells through conjugation to a tumour-cell-specific small-molecule ligand, thereby reducing delivery to normal cells and the associated collateral toxicity. This Review describes the major principles in the design of ligand-targeted drugs and provides an overview of ligand–drug conjugates and ligand–imaging-agent conjugates that are currently in development It is a powerful pharmaceutical strategy to achieve selective drug delivery to pathological cells, for both therapeutic and diagnostic purposes, this active drug targeted approach is based on the discovery that there are receptor overexpressed on pathological cells, compared to their expression in normal tissues. Recent studies high lights the ligand density plays an important role in targeting efficacy. Furthermore, LTT applications in diseases form cancer and those exploiting receptor overexpressed at cytoplasmic level are growing.

Keywords: Cancer, Toxicity, Tumour, Ligand, Liposomes, Receptor mediated targeting.

[Full Text Article]


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