Abstract
CLINICAL SIGNIFICANCE OF BLOOD TRANSTHYRETIN LEVEL AS A NON-INVASIVE PROGNOSTIC INDICATOR FOR PATIENTS OF DEPRESSION – A PILOT STUDY

*Dr. Vanita Lal, MBBS(Hons) MD,DNB and Garima Gupta

ABSTRACT

Introduction: Transthyretin (TTR) is a major transporter of thyroxine hormone. Alterations in TTR have been found to be associated with neurogenerative disorders. Thus the current study aimed to evaluate the clinical significance of serum transthyretin levels among cases of depression and healthy control subjects. Materials & Methods: Total 100 euthyroid cases with depression and 50 healthy subjects were included in the study. Degree of depression was evaluated using 17-item Hamilton Depression Scale. Present study analysed the level of Serum transthyretin, and other thyroid binding globulin, albumin, globulin, thyroid hormone, thyroid stimulating hormone were measured. Result: According to the Hamilton Depression Scale, 37 (37%), 37 (37%) and 26 (26%) patients were found to have mild, moderate and severe depression respectively. In cases of depression TTR was found to be 22.84 mg/dl however, in healthy control subjects 28.43mg/dl was observed was found to be significant (p<0.0001). Cases of depression with degree of depression such as mild, moderate and severe, TTR was 25.14mg/dl, 22.28mg/dl and 20.39mg/dl respectively (p<0.0001). Increase level of TSH level was observed in cases of depression (3.75 mIU/L) however, in healthy control subjects 2.34 mIU/L was observed and differences was found to be significant (p=0.02). Distribution of Serum Albumin Level (SAL) among cases of depression was 34.70 mg/dl while in healthy subjects 30.90 mg/dl was observed and difference was found to be significant (p=0.0009). Degree of depression such as mild, moderate and severe had 11.84, 15.08 and 19.46 HDRS score (p<0.0001). Significant negative correlation (r -0.74, p<0.0001) was observed of TTR with HDRS score among cases of depression. Conclusions: The present study suggests that serum TTR could be good noninvasive predictive indicator for depression and could help to access the severity of disease and its prognosis.

Keywords: Transthyretin, Degree of Depression, Hamilton Depression Scale.


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