Abstract
BENZIMIDAZOLE: A PROPITIOUS SCAFFOLD WITH MULTIFARIOUS THERAPEUTIC POTENTIAL

Shubham Keni*, Dr. Ashok Pingle and Rasika Bhogate

ABSTRACT

Most of the drugs and pharmacologically active moieties possess heterocyclic ring structure and presence of hetero atoms or groupings evinces privileged specificities in their pharmacological targets. Among the heterocyclic compounds, benzimidazole has emerged as cardinal construction motif, which plays pivotal role in drug development. Benzimidazole scaffold is known to possess some prime pharmacological activities like anti-mycobacterial, antimicrobial, anti-viral, anti-oxidant, anti-inflammatory, anti-hypertensive, etc. This broad spectrum of biological and biochemical activities has been further assisted by the synthetic flexibility of benzimidazole, which permits development of large no of structurally diverse derivatives. Therefore, it is necessary to compile the latest information along with earlier information to understand present status of benzimidazole nucleus in drug discovery. In the present review, various derivatives of benzimidazole possessing anti-mycobacterial, antimicrobial, analgesic and anti-inflammatory potential are brought into limelight and their activity has been elucidated in accordance with structure activity relationship studies.

Keywords: Benzimidazole, Anti-mycobacterial, Anti-Microbial, Analgesic, Anti-inflammatory.


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