Abstract
REVIEW ARTICLE: CO-CRYSTAL AND SELECTION OF ITS CO-FORMER

Anand D. Savkare* and Ashish V. Ther

ABSTRACT

Poor aqueous solubility and bioavailability of an active pharmaceutical ingredient are major problem in development of new product. Pharmaceutical co-crystals are new class of solid drugs with improved physicochemical properties. In this paper systematic overview of pharmaceutical co-crystals is provided. With special emphasis on difference between co-crystal, salt and solvate, preparation methods, physicochemical properties of co-crystal. As co-crystals are crystalline material made up of two or more components i.e API and co-formers, usually in a stoichiometric ratio, each component being an atom, ionic compound, or molecule. So brief overview on various co-former screening methodology including supra-molecular synthon approach which utilizes Cambridge structural database (CSD), Pka approach, Hansson solubility parameter are explain and correlate with co-crystal formation.

Keywords: Pharmaceutical co-crystal, Crystal engineering, Solution co-crystallization, Supra-molecular synthon, CSD, Hansen solubility parameter.


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