Varsha Bhagavatprasad Trivedia*, Anis Ahmad Chaudhary, Sarat Kumar Dalaia and Hargovind Laxmishakar Trivedic


Donor-specific antibodies (DSA) have proved awell established biomarker predicting antibody against the human leukocyte antigen (HLA)-A, -B, and -DR loci. It has detrimental effect on renal allograft outcomes including high incidence of antibody-mediated rejection, graft dysfunction, inferior graft survival and poor transplant outcomes. Inadequate data is available describing the incidence and impact of denovo HLA-DQ antibodies. 644 renal transplant recipients without pre-transplant donor-specific antibodies over the period of four years from the western part of India were examined. 23% (157/644) patients developed donor-specific antibodies, in which 17.8% (28) had a HLA-class I and 82.6% (129) had class II antibodies.55.8% (72) class II positive patients developed denovo DQ antibodies. The mean of serum creatinine and proteinuria was significantly higher in HLA-DQ antibodies developed patients than those without antibodies.18.05% (13/72) denovo positive patients rejected grafts. The study is conclusive that the donor-specific HLA-DQ antibodies were the most common type detected and these antibodies may contribute to poor graft outcomes.

Keywords: Antibody-mediated Rejection (AMR), Kidney Transplantation, denovo Donor Specific Antibody (dnDSA), HLA-DQ Antibody.

[Full Text Article]


Forgot Password  |  Register


Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation


    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.


UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS


Copyright From

Covering Letter

                        Author Instruction