Abstract
STABILITY-INDICATING SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF MEBENDAZOLE IN PURE FORM AND PHARMACEUTICAL PREPARATION

Khalid Abdel-Salam M. Attia, Mohammed W.I. Nassar, Mohammed El-Dosoky and Ahmed W. Madkour*

ABSTRACT

Four simple, rapid, sensitive, accurate and precise stability-indicating spectrophotometric methods were developed for the determination of mebendazole in bulk powder and in pharmaceutical preparation. Method (A) derivative ratio method (1DD); is used for the determination of intact mebendazole in presence of its degradation product at 223 nm in the range of 1 - 9μg ml-1 with LOD of 0.082μg ml-1 and LOQ of 0.250 μg ml-1, Method (B) ratio difference method; is based on measuring the difference in the amplitude of intact mebendazole in presence of its degradation product at two different wavelengths ,this is done at 218nm and 230 nm in the range of 1 – 9 μg ml-1 with LOD of 0.187 μg ml-1 and LOQ of 0.567 μg ml-1., Method (C), mean centering method; the method was applied for analysis of mebendazole in presence of its degradation product this is done at 274 nm in the range of 1 – 9 μg ml-1 with LOD of 0.108 μg ml-1 and LOQ of 0.329 μg ml-1., Method (D) Bivariate method, is used for the determination of intact mebendazole in presence of its degradation product at 215&235 nm in the range of 1 – 9μg ml-1 with LOD of 0.269 μg ml-1 and LOQ of 0.816 μg ml-1 at (215 nm) and with LOD of 0.155 μg ml-1 and LOQ of 0.470 μg ml-1 at (235 nm).The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision.

Keywords: Mebendazole, Derivative ratio, Ratio difference, Mean centering, Bivariate, pharmaceutical preparation.


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