Abstract
GLUTATHIONE S-TRANSFERASE M1 GENE DELETIONS AND THEIR EFFECT ON IRON STATUS IN RENAL FAILURE PATIENTS

*Nosiba Abdalraouf, Nadia Madani Mohamed and Ibrahium Khidir

ABSTRACT

Background: Renal failure is one of endemic disease in sudan characterized by chronic and acute renal failure. The renal failure disorder differs in etiology and symptoms and in the consequence of disease. Deletion in Glutathione S-transferase M1 gene polymorphism in renal failure patient this problem may be cause of increase serum ferritin. Objectives: To detect Glutathione S-transferase M gene null genotype and their effect on iron status in patients with renal failure in Khartoum state. Materials and Method: A case control study was done in 50 renal failure patients and 40 normal controls. Included measurement of serum ferritin level by TOSO machine and Assessment of GST M1 polymorphisms by allel specific PCR approach briefly. Results: The GSTM1null genotype was present in (0%) of the renal failure patients. There was an insignificant association of GSTM1null genotype (P = 0.004) with effect on iron status in patients with renal failure. Conclusion: The GSTM1null genotype was not associated with effect on iron status in patients with renal failure in Sudan- Khartoum state.

Keywords: Renal failure, GSTM1 (Glutathione S-transferase), Ferritin, TOSO machine, allele specific PCR.


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