Deelip Derle*, Sachin S. Bhagat and Dipak D. Nemane


In the 1980s, orally disintegrating tablets (ODTs) were introduced in the market becoming one of the most useful techniques of drug delivery. The target populations for ODTs are bedridden pediatric, geriatric, and or disabled patients. Patients with persistent nausea, who are traveling, have little or no accesses to water are also good candidates. Sustained release technology is considered a useful drug delivery method in the pharmaceutical industry, that managed to overcome the limitations of conventional dosage forms and succeeded to improve the therapeutic efficacy, patient compliance and convenience of handling. The basic concept of formulating SR-ODTs involves formulating the drug coated or encapsulated in a matrix to form a multi-particulate drug system These include the use of ion exchange resin systems, microencapsulation, nanoparticles, pellets and stimuli-responsive polymers. Each approach has its own characteristics & use in sustained drug release through the ODT. Sustained release ODT can offer advantages of both, ODT technology and sustained release technology, which provide additional clinical benefits to patients.

Keywords: Sustained Release ODT, Microencapsulation, Ion exchange resin, Pellet, Stimuli-response polymer, Diffucaps.

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