Abstract
REVIEW ON: CONVENTIONAL AND NOVEL TECHNIQUES FOR SOLUBILITY ENHANCEMENT

Dipak D. Nemane*, Sanjay P. Anantwar and Sachin S. Bhagat

ABSTRACT

The most challenging task in drug development is enhancement of solubility and permeability. About 40% new chemical entities (NCEs) rejected in drug discovery program due to its low aqueous solubility. Solubility, Dissolution rate of drug and it's release from dosage forms have ascendance on bioavailability. Major challenges for formulation scientist is the low aqueous solubility which can be solved by different conventional and novel technological approaches includes micronization, nanonization, use of salt forms, use of surfactants, solid dispersion, complexation, liquisolid technique etc. This article gives detailed information about different conventional and novel technologies used to enhance solubility and dissolution rate of poorly water soluble or hydrophobic drugs.

Keywords: Hydrophobic, Solubility, Bioavailability, Solid Dispersion, Liquisolid.


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