Abstract
EMBRACING THE QUALITY IN ALTERNATIVE ORAL DRUG DELIVERY SYSTEM: ORAL DISINTEGRATING TABLET (ODT)

Arjit Saxena*, Ritesh Kumar Tiwari and Lalit Singh

ABSTRACT

By performing the present literature survey it is ensured that ODT plays a vital role towards the oral drug delivery systems to target the efficacy, safety and patient acceptability. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating tablet (ODT). These Oral disintegrating tablets have superiority as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional tablets as they can be used for verities of diseases and are taken without water due to their ability to disintegrate within a few seconds releasing drug in mouth. Various approaches are employed for formulating ODTs. Generally; hydrophilic polymers along with other excipients are used for preparing ODTs which allow Tablet to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating tablets have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on quality system in ODTs formation, approaches for formulation and evaluation of ODTs.

Keywords: ODT (Oral Disintegrating Tablet), QbD (Quality by Design), Oral Drug Delivery System.


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