Abstract
REVIEW OF p53

Dr. Prashant Rao, Dr. V. V. Kulkarni, Dr. Mayur Choudhary, Dr. Prasad Karande and Dr. Shrikant Sonune*

ABSTRACT

The tumor suppressor gene, p53, is the most commonly mutated gene in human cancers. P53 an open reading frame of 393 amino acids, the p53 gene has 11 exons with several conserved domain. Under normal circumstances, p53 protein is present in the cell at extremely low levels with the protein being relatively inactive and inefficient at binding target DNA. Various types of stress increase p53 protein levels in the cell and these include DNA damage, heat shock, hypoxia, hyperoxia, cytokines, growth factors, metabolic changes, oncogenes. This subsequently results in adaptive cum protective responses. Loss of normal p53 function is potentially harmful when cells with damaged DNA are left unchecked and permitted to continue replicating. This review emphasize various aspects of P53.

Keywords: Mutations, Oncogenesis, p53.


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