Abstract
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SUBSTITUTED SALICYALDEHYDE SCHIFF BASE DERIVATIVE

Shere Priti H.*, Shaikh Amreen S. and Khobragade Chandrahasya N.

ABSTRACT

The new Substituted salicyaldehyde Schiff base derivative was synthesized by condensing 3,5- dibromosalicyladehyde with 4-chloroaniline in ethanol in the presence of glacial acetic acid Forming new substituted schiff base derivative 2,4-dibromo-6{[4-methylphenyl)imino]methyl}phenol]. Synthesis was ascertained with 1HNMR, FTIR and Mass spectroscopic studies. Substituted Schiff base derivatives were evaluated for their antimicrobial potential. Schiff derivative investigated have shown significant antimicrobial activity against bacteria Escherichia coli, Staphylococcus aureus and fungus candida albicans.

Keywords: Schiff derivatives, 1HNMR, FTIR, Mass Spectroscopy, Antimicrobial activity.


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