Abstract
A NEW VALIDATED RP-HPLC METHOD FOR DETERMINATION OF CIPROFLOXACIN AND ORNIDAZOLE IN BULK PHARMACEUTICAL DOSAGE FORMS

S. Janet Beula*, Dr. R. Suthakaran, R. Jeevana, Prem Kumar Bichala, Ch.Shankar and J. Shiva

ABSTRACT

It is a simple and selective RP-HPLC method for the determination of ciprofloxacin and Ornidazole bulk pharmaceutical dosage form. Chromatographic separation was achieved on a c-18 column using mobile phase consisting a mixture of methanol, Acetonitrile, dichloromethane, water, 0.1N NaOH, 0.1 N Hcl with detection of 295nm. Linearity was observed in the range of 50 g/ml for ciprofloxacin and 40 g/ml for Ornidazole. R2 = ciprofloxacin (0.0160) and Ornidazole (0.871) for the amount of drugs estimated by the proposed method was in good aggremented with the lable claim. The proposed method was validated. The accuracy of the methods was assessed by recovery studies at two different levels. Recovery experiments indicated the absence of interference from commonly encounter pharmaceutical additives. The method was found to be presized as indicated by the repeatability analysis showing ≥ 2. All statistical data proves validity of the method and can be used for routine analysis of pharmaceutical dosage form.

Keywords: Liquid Chromatography (LC) RSD (Relative Standard Deviation), correlation co-efficient (r2).


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