Abstract
SYNTHESIS AND ANTIMALARIAL ACTIVITY OF CINNAMIC ACID DERIVATIVES

Rokhyatou Seck, Malamine Mansaly, Abdoulaye Gassama*, Christian Cavé and Sandrine Cojean

ABSTRACT

A peptide coupling reaction between 1-(R)-phenylethylalanine and cinnamic acid derivatives has been successfully employed for the synthesis of a set of small molecules. The antimalarial activity of these derivative molecules is reported. The compounds have been evaluated against chloroquine-sensitive (3D7) and chloroquine-resistant (W2) strains of P. falciparum as well as their cytotoxic activity against HUVEC cells. For 3D7, the most active molecule was compound 8 with IC50 of 23.6 nM comparable to that of chloroquine (18.5 nM). The products were characterized by IR, NMR and MS analysis.

Keywords: Peptide coupling, cinnamic acid, Reagent-based diversity, Antimalarial, P. falciparum.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW APRIL ISSUE PUBLISHED

    APRIL 2019 Issue has been successfully launched on 1 April 2019

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT