Abstract
AN OPEN LABELED CLINICAL STUDY ON EVALUATING THE DE-ADDICTION EFFICACY SIDDHA DRUG KOTHTHAMALLI VITHAI CHOORANAM IN TREATING ALCOHOLISM (KUDIVERI NOI)

Dhanalakshmi R.*, Sureka A., Anbarasan K., Madhavan R., Banumathi V.

ABSTRACT

Alcoholism commonly called by its name Kudiveri noi in siddha system of traditional medicines is considerably has created huge socio economic impact in both developing and developed countries. WHO estimates that about 76 million individuals worldwide are diagnosable alcohol use disorder (AUD) either with alcohol misuse or alcohol dependence. These numbers are anticipated that would be increment every year as it happen to the worldwide danger. Liver is the primary metabolic organ which were been affected with continuous and uncontrolled consumption of alcohol in excess and thus it become a leading cause of cirrhosis, liver cancer, and acute and chronic liver failure and as such causes significant morbidity and mortality. Increase in liver function enzymes and audit score is considered to be the severity scale of the alcoholism index. By considering the complexity in treating the AUD researchers are at constant search of exploring a drug which could acts in multiple ways and offers physiological and psychological support to the affected individuals. Principal of siddha medicine is to make the body perfect, imperishable and to promote longevity. This is the first system to emphasis health as the perfect state of physical, mental, social, moral and spiritual component of human beings. Present study aimed at evaluating the de-addiction efficacy of siddha formulation Koththamalli vithai chooranum (KVC) in patients with alcoholism. A total of 30 patients who are presented with pathology of the alcoholism along with secondary complication have been selected for the trial and were treated with KVC for the period of 48 days. It was observed from the clinical outcome of the present study that patients treated with KVC has shown significant reduction in serum glutamic oxaloacetic transaminase (SGOT) and Serum glutamic pyruvic transaminase (SGPT) level including audit score. Hence it was concluded from the outcome of the present study that reduction in biologically significant enzymes may be taken as good indication of liver rejuvenation and further this action of dug could be due to bioactive components present in the formulation which has tendency to halt the progression of liver damage caused due to AUD.

Keywords: Alcoholism, Siddha medicine, Koththamalli vithai Chooranum, AUD, SGOT, SGPT.


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