Abstract
DERMATOLOGICAL PHARMACOLOGY OF AQUEOUS AND ETHANOL LEAF EXTRACTS OF MUCUNA PRURIENS

*Ohadoma S. C. and Lawal B. A. S.

ABSTRACT

Objective: To assess the dermatological activity of Mucuna pruriens leaf extracts with particular emphasis on the antifungal and wound-healing effects. Methods: The crude aqueous as well as ethanol extracts of the dried leaves of M. pruriens were obtained by 72 h maceration in water and ethanol respectively. The extracts were investigated employing modified agar-well diffusion method, while the wound-healing activity was determined using standard method, in which three groups comprising five mice each were used. Groups II and III received 10% and 20% extract/petroleum jelly(Vaseline) mixture respectively. Group I received Vaseline only and served as negative control. Results: The aqueous leaf extract showed lesser pronounced antifungal activity against Aspergillus spp and Candida albicans than the ethanol extract. Observed on wounds treated with 10% and 20% extract/Vaseline mixture was considerable signs of dermal healing compared to control(Vaseline) only. Conclusion: Mucuna pruriens leaf extracts accelerated wound-healing process and exerted antifungal effect in albino mice.

Keywords: Mucuna pruriens, antifungal, wound-healing, dermatological activity, test microorganisms.


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