Abstract
SOLID DISPERSION

Aietesam Mohiuddin* and Atika Tahreem

ABSTRACT

Introduction: The enhancement of oral bioavailability of poorly water-soluble drugs remains. One of the most challenging aspects of drug development. Although salt formation, Co-solubilization and particle size reduction have commonly been used to increase . Dissolution rate and thereby oral absorption and bioavailability of such drugs there are practical limitations of these techniques. The increase in drug dissolution rate from solid dispersion system can be attributed to a number of factors like particle size, crystalline or polymorphic forms and wettability of drug etc. Objectives: The objectives of solid dispersion are. 1. Formulation of solid dispersion for the improvement of solubility and dissolution characteristics of gliclazide. 2. Characterization and confirmation of amorphous dispersion. 3. Characterization of solubility, dissolution rate and stability. 4. In vivo evaluation of bioavailability. Conclusion: The aim of current investigation was to prepare and evaluate third generation solid dispersions of Ibuprofen using modified Guargum as carrier. The prepared solid dispersions were characterized for preformulation parameters, percentage yield, drug content, solubility study,Invitro dissolution and stability study. The solid dispersions were prepared by solvent evaporation method and Melt dispersions method. The flow properties of formulations F1-F6 were found to be satisfactory. Percentage yield was in the range 85-99%.The In-vitro release of formulation was in the range 27.33- 82.31. F2 was found to be having a better release among all the formulations. Stability study was performed for one month and was found to be stable.

Keywords: Bioavailibility, Co-solubilization, Guargum, Evaporation, Preformulation.


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