Abstract
PRELIMINARY PHYTOCHEMICAL SCREENING AND TOXICITY EVALUATION OF DIFFERENT EXTRACTS OF TERMINALIA BELLERICA

S. Elavarasi*, Horne Iona Averal and Cybil Ignatius

ABSTRACT

The present study aims to test the acute toxic effect of the fruit extract of Terminalia bellerica using three different solvents viz ethanol, acetone and benzene by examine the changes in behaviour, body weight, food intake, water intake, haematological parameters (WBC total count, WBC differential count, RBC, Hb, HCT, MCV, MCH, MCHC and platelet count) and histological changes in the vital organs such as lungs, heart, liver and kidney. No behavioural changes or any toxic symptoms and mortality was observed throughout the experimental period. There is a slight variations in the body weight, food intake and water intake of the extract treated groups compared to control group rats. The haematological parameters showed significant difference among the different extract treated rats and control rats, but the levels are not exceeded from the normal range. The microscopic and macroscopic examination of the vital organs such as lungs, heart, liver and kidney showed normal cell structures, blood vessels and nuclei. Thus the present study revealed that the ethanol, acetone and benzene extracts of Terminalia bellerica fruit did not produce any toxic effects at the high dose of 2000mg/kg body weight and is found to be safe. Thus it is concluded that the plant extract of Terminalia bellerica fruit upto 2000 mg/kg body weight was used for further evaluation studies.

Keywords: Terminalia bellerica, Toxic effect, Albino rats, Body weight, Food and water intake, Haematology, Histology.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW MARCH ISSUE PUBLISHED

    MARCH 2019 Issue has been successfully launched on 1 March 2019

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT