Abstract
FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF MECP2 GENE WHICH IS RESPONSIBLE FOR RETT SYNDROME

*P. Divya and K. Shoba

ABSTRACT

Rett syndrome is dueto a genetic mutation of the MECP2 gene. This gene occurs on the x chromosome typically it developed as a new mutation, with less than one percent of cases being inherited from a person parent. If occur almost exclusively in girls. Rett syndrome is a genetic brain disorder which typically becomes apparent after 6 to 18 month of age in female. MECP2 (methyl CPG binding protein 2) is a gene that encodes the protein MECP2.MECP2 appears to be essential for the function of nerve cell. The sequence of protein retrieved from national Centre for biotechnology information in fasta format. The structural analysis of MECP2 were carried out by using bioinformatics tools like scanprosite, blast-p,T -coffee, gene card, MHC, Aceview…etc.

Keywords: Rett syndrome, methyl CPG binding protein 2, NCBI, scanprosite, blast-p, T coffee, gene card, MHC, Aceview.


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