Abstract
PREPARATION AND EVALUATION OF MICROSPHERES OF DICLOFENAC SODIUM-RICE BRAN WAX

Indurwade N. H.*, Chaudhari Sunil B., Dodani K. M. and Wanve A. G.

ABSTRACT

Objective: The objective behind the study was to develop Diclofenac sodium loaded biocompatible microspheres to reduce the side effects of Diclofenac sodium and sustain the release of drug for a prolonged action. Methods: The microspheres were prepared by emulsification technique; the lipophilic wax was poured into water dropwise using Tween-80 as surfactant. Results: The prepared microspheres were evaluated for particle size, drug entrapment efficiency (EE) and in vitro drug release study. The mean particle sizes were found to be 8.58μm, 9.387 μm and 9.98 μm respectively for the three formulations M1, M2 and M3 representing drug polymer ratio 1:1, 1:2 and 1:3 respectively. The values of cumulative percentage of drug released during 7 hours for the three formulations M1, M2 and M3 were found to be 68.02, 65.02 and 60.24 respectively. Conclusions: The result reveals that the particle size and EE increases as the polymer content in the formulation increases. The increase in polymer concentration prolonged the release of drug from the microspheres with a sustained release pattern. Hence, the microspheres of Diclofenac sodium with rice bran wax were satisfactorily prepared.

Keywords: Diclofenac sodium, Rice bran wax, Sustained release, Biocompatible microspheres.


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