Abstract
POLYMORPHISM, CRYSTALLINITY AND HYDROPHILIC-LIPOPHILIC BALANCE (HLB) OF CETEARYL ALCOHOL AND CETYL ALCOHOL AS RAW MATERIALS FOR SOLID LIPID NANOPARTICLES (SLN)

Thallysson Carvalho Barbosa, Conrado Marques, Daniele Martins, Luciana Nalone, Salvana Costa, Kahynna Loureiro, Marco V. Chaud, Classius F. da Silva, Eliana B. Souto,*, Raquel de Melo Barbosa and Patrícia Severino*

ABSTRACT

The use of Solid Lipid Nanoparticles (SLN) has become a very popular approach in the development of innovative pharmaceutical drug delivery systems. The first step is the assessment the lipids’ suitability. This paper is focused on the physicochemical characterization of lipids, namely cetyl alcohol and cetearyl alcohol, for the production of SLN. The bulk lipids were analyzed by Differential Scanning Calorimetry (DSC) and Wide Angle X-ray Diffraction (WAXD) without any treatment, after tempering the raw materials (bulk lipid) for 1 hour at 80ºC, and after their spray-drying process. Hydrophilic Lipophilic Balance (HLB) values were determined using a combination of surfactants (polysorbate 20 and trioleate sorbitan) for the production of the hot o/w emulsion. Results of DSC and WAXD showed that after the thermal stress applied to the bulk lipids, both the melting point and the intensity of the refractogram peaks have decreased. Cetyl alcohol and cetearyl alcohol crystallized in more unstable polymorphic forms, which anticipate the suitability of these lipids for the production of SLN. The best HLB values obtained for the produced emulsions were 15.5, 16.0, and 16.7, combining accepted surfactants. The results showed that both cetearyl alcohol and cetyl alcohol are adequate lipids for the development of stable SLN.

Keywords: Cetearyl alcohol; cetyl alcohol; lipid polymorphism; hydrophilic lipophilic balance; solid lipid nanoparticles.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW MARCH ISSUE PUBLISHED

    MARCH 2019 Issue has been successfully launched on 1 March 2019

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT