Abstract
FORMULATION DEVELOPMENT OF FAST RELEASING ORAL THIN FILMS OF CAPTROPRIL

G. Tejawini, I. Sai Charitha, N. Surya Naik, G. Sunitha, T. Ravi Kumar, Ch. Saibabu, Ch. M. M. Prasada Rao, Jhansi Priya Marabathuni*

ABSTRACT

Captopril films were prepared by solvent casting method using different grades of HPMC (E5, E50 and K4M). Sixteen formulations (FV1-FV16) of captopril films were prepared and evaluated for their physical characteristics such as thickness, tensile strength, elongation, weight variation, folding endurance, drug content uniformity and surface pH and gave satisfactory results. The compatibility of the drug in the formulation was confirmed by FTIR and DSC studies. The formulations were subjected to disintegration, in vitro drug release .Formulation F2,F8,F14 was found to be best formulations which contain 4% captopril shows excellent film forming characteristics such as disintegration time of 57 sec and percentage drug release 95.95% within 10 minutes. The optimized film formulation (FV5) showed excellent stability over 45 days when stored at 40°C/60% relative humidity. The pharmacodynamic study of captopril FDF in SHR proved the better therapeutic efficacy.

Keywords: Captopril, fast releasing oral thin films, In-vitro release.


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