Abstract
HISTOCHEMICAL DETECTION OF MUCIN IN CANCER COLON AND ITS RELATION TO HISTOLOGICAL GRADE

Howaida Mahmoud Hagag, Hayfa Ali Al-Saif, Amal Fathy Gharib, Asmaa Farghaly Hassan, Nora Musaad Al harthi, Nweir Musaad Al harthi and Khadiga Ahmed Ismail*

ABSTRACT

Background: Colon cancer is one of the major reasons of morbidity and growing mortality rate around the world. Colon cancer is the third most popular cancer in the world with about one million new cases of Colon cancer identified every year. Mucin production by the tumor cells has an influence on the prognosis and therapeutic management. The aim of this study was to assess the mucin content in the tumors histochemically and to associate the mucin content with the histological grading of the Tumors. Subjects and methods :Retrospective study was conducted on 30 cases of diagnosed colorectal carcinoma, by collecting important clinical and gross examination data from patient’s files, doing histopathological examination and histochemistry using Periodic Acid Schiff’s (PAS). Results: The study showed the peak incidence of colorectal carcinoma was above the age of 50 years (73%) and the patients were predominantly males (60%). The most predominant histological type of colorectal carcinoma in our study was adenocarcinoma (30 cases) from which 6 cases (20%) have mucin content more than 50% and categorized as mucinous adenocarcinoma. The common detected grade was the intermediate grade (58.3%), and the common site was the rectum (40%). From 30 studded cases, mucin positivity was seen in 24 cases (80%) and negative in 6 cases (20%), out of these 24 cases the marked mucin stain were seen in the mucinous carcinoma and high grade non mucinous carcinoma, the moderate mucin stain were detected mainly ingrade 3 carcinoma (64.3%), the mild mucin stain detected in some cases of grade 2 carcinoma (35.7%) while all cases (6 cases) of grade 1 were negative for mucin. Conclusion: Mucin positivity was prominent in intermediate and high grade tumor cases and absent in low grade tumors. So the use of both histopathological tumor grade and histochemical mucin detection can be valuable prognostic indicators for patients of colorectal carcinoma outcomes.

Keywords: Colorectal Carcinoma, Histochemistry, Mucin, PAS Stain.


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