Abstract
DETERMINATION OF THE ANTIBACTERIAL EFFECTS OF ETHANOLIC EXTRACT OF MORINGA OLEIFERA LEAVES ON BACTERIAL ISOLATES FROM WOUND INFECTIONS

Bunza N. M.*, Kumurya A. S., Abdul Azeez B. O., Ashcroft O. F., Kalgo M. U. and Nafiu F.

ABSTRACT

Moringa oleifera is a medicinal substance that is used in the treatment of many infectious and non infectious ailments. In this study, the antibacterial activities of the crude ethanolic extracts of Moringa oleifera leaves on four bacterial wound isolates were determined, namely; S. aereus, P. aeruginosa, E. coli and P. mirabilis. The activity patterns of the crude extract was determined using Kirby-Bauer disc diffusion and Punched Holes techniques. Similarly, minimum inhibitory concentrations (MICs) of the extract were determined using Macrobroth dilution techniques as well as minimum bactericidal concentrations (MBCs). Phytochemical screening of the crude extract of Moringa oleifera was also carried out. Highly significant activity was observed with the crude extract of M. oleifera on P. mirabilis (at 125mg/ml, 250mg/ml and 500mg/l, p = 0.037), followed by its effect on S. aureus (125mg/ml, 250mg/ml and 500mg/ml, p = 0.046). Lower activity was observed with the plant on P. aeruginosa and E. coli. The overall results of the present study support that, the crude extracts of M. oleifera leaves could be considered as a potential source of novel antibacterial agents which may be employed to forestall the present antibiotic resistance menace.

Keywords: Moringa, Bacteria, Wound, Ethanol, Infection.


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