Abstract
REVIEW ON PRONIOSOMES AS A NOVEL CARRIER FOR NOVEL DRUG DELIVERY SYSTEM

Dr. Shaikh Siraj N.*, Irshad Ahmad Mohd. Salim, Dr. G. J. Khan, Band Afzal Abdul Razzak and M. Y. Khalifa

ABSTRACT

Proniosomes are liquid crystalline compact niosome hybrids which upon hydration form niosomes. It is drug with larger physical and chemical stability and potentially scalable for commercial viability. Proniosomes overcome the disadvantages associated with niosomal and liposomal drug delivery systems. It can act as drug reservoirs and the rate of drug release can be controlled by change of their composition. Proniosomes have presented benefits as drug carriers such as less charge, small toxicity. Proniosomes are used as carrier in novel drug delivery system, in which the medication is encapsulated in a vesicle and provide various pharmaceutical and cosmetic presentations. Proniosomes are generally made by spraying surfactant in organic solvent onto carrier and then evaporating the solvent. Proniosomes are dry preparation of water-soluble carrier particles that are coated with surfactant and can be hydrated to form niosomal dispersion directly before use on brief excitement in hot aqueous media within actions. Proniosomes are superior to niosomes by showing high physical and chemical stability, developed drug targeting with less manufacturecost. Many types of drug deliveries can be possible using proniosomes based niosomes like targeting, ophthalmic, topical, parenteral, oral vaccine. This review focus on advantages, types Proniosomes and their preparation, characterization and their applications in Novel drug delivery.

Keywords: Surfactants, Enhances, Liquid Crystalline, Biodegradable, Carrier.


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