Abstract
PHYTOSOMES, A NOVEL STRATEGY TO IMPROVE THE BIOAVAILABILITY OF FLAVONOIDS: A REVIEW

*Pankaj Sharma, Lakshita Dogra, Diksha Thakur, Oshina, Smily and Dolly Chauhan

ABSTRACT

Phytosome are the small cell like structure which serve as a intermediate between conventional and novel drug delivery system. Phytosome are able to carry drug themselves from to the hydrophilic to the lipophiliic environment of the cell membrane, which ultimately reaches to blood. The hydrophilic constituent has find their application in the various disorder treatment such as skin disorder, anti-ageing process, antimicrobial, antitumor which cannot be treated with conventional delivery system and hence transformed into phytosomes. Phytosome complex is to be prepared by mixing of polyphenolic constituents and phosphoatidylcholine in molar ratio. Phytosome are superior to the conventional drug delivery system in term of pharmacokinetics and pharmacodynamic properties. Phytosomal delivery of extract of silybin, grape seed, hawthorn, centella, olive oil etc. has been profitable use. Phytosomes have been refined the therapeutic uses like hepatoprotective, cardioprotective, antihypertensive, anti-inflammatory, vein and skin disorder etc. or for preventive of health reasons. In the ever-expanding horizon, phytosome as a modern technology increasing for drug bioavailability as well as efficiency of drug delivery system.

Keywords: Phytosomes, flavonoids, bioavailability, phospholipids.


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