Abstract
SERUM LEPTIN LEVELS AND SERUM CHOLESTEROL LEVELS IN PATIENTS ON WEIGHT NEUTRAL ANTI DEPRESSANTS

Chandima Jinani Herath*, Praveen Kumar Vodala, Bharathi Dharavath, Suprada S Vinyak, Mohamed Aly Elsherif, Sajiny John, Wesam Eddin Rahima, Ibrahim Mohammad Sabri, Asma Gilani

ABSTRACT

Background: Weight gain is a well-known side effect of almost all anti-depressants. With weight gain there are changes in Leptin levels and changes in the levels of LDL cholesterol, HDL cholesterol and total cholesterol. IN this study, we tried to compare the changes in these parameters in regular anti-depressants and in weight neutral anti-depressants. Methods: In this study, we took a total of 143 patients. Out of these patients, 95 patients were on regular anti-depressants and 48 patients were on weight neutral antidepressants. We measured serum Leptin levels at the beginning of the study and then 6 months after the patients were on the medications. All the patients were fully compliant with their medications. Results: In our study, we found that the serum Leptin level was 57.5±6.4 in group A and 58.1±5.3 in group B. After 6 months, it was 49.6±5.4 and 52.4±4.3 respectively. Total cholesterol level increased to 208.7±27.12 from 201.8±30.41 and in group B it increased from 197.2±96 to 232.8±22.95. On applying student’s t test, p value was found to be 0.001 which is statistically significant. HDL levels and LDL levels also showed statistically significance in group A and group B. Conclusion: There was an increase in serum Leptin levels and increase in dyslipidaemia in patients on regular anti-depressants as compared to weight neutral anti-depressants.

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