Abstract
A NOVEL APPROACH TO ENHANCE BIOAVAILABILITY OF DALFAMPIDINE BY FORMULATING AS HYDROGEL BEADS USING NATURAL POLYMERS

Swarupa Arvapalli*, Md. Nabeel Ahmed, G. Jyosthna and J. V. C. Sharma

ABSTRACT

The current research deals with formulation and evaluation of hydrogel beads of Dalfampridine by using natural polymers. These hydrogel beads were prepared with the objective to enhance bioavailability and to produce sustained release of dalfampridine. More over the Hydrogel beads of Dalfampridine are prepared by ionotropic gelation method. In the present work, a total of nine formulations were formulated, using natural polymers like xanthan gum, guar gum, and tamarind gum along with sodium alginate as a gelling agent. The formulated Dalfampridine Hydrogel beads were then assessed for various parameters viz., FTIR, SEM, particle size, size distribution, % yield, drug content, entrapment efficiency, in vitro dissolution, release kinetics. The invitro dissolution data for best formulation F9 were fitted in different kinetic models i.e, zero order, first order, Higuchi and korsemeyer-peppas equation. Optimized formulation F9 shows R2 value 0.989. As its value nearer to the ā€˜1ā€™ it is conformed as it follows the zero order release. The mechanism of drug release is further confirmed by the korsmeyer and peppas plot. The ā€˜nā€™ value is 1.220 for the optimised formulation(F9) i.e., n value was >0.89 this indicates Super case transport. From the drug release kinetics of the Dalfampridine hydrogel beads it was concluded that the formulation F9 follows Zero order release with super case transport mechanism.

Keywords: Dalfampridine, Hydrogel beads, Ionotropic gelation method, FTIR, SEM, Entrapment efficiency, In vitro dissolution.


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