Abstract
ASSOCIATION OF XENOBIOTIC GENETIC VARIANTS WITH OXIDATIVE STRESS IN TYPE 2 DIABETES MELLITUS

Dr. R. Dhananjayan*

ABSTRACT

Xenobiotics are defined as any foreign substances or exogenous chemicals which the body does not recognize such as drugs, pollutants, as well as some food additives and cosmetics. The body removes xenobiotics by xenobiotic metabolism. This consists of the deactivation and the excretion of xenobiotic and happens mostly in the liver. Hepatic Microsomal Cytochrome P450 is a group of enzymes involve in xenobiotic metabolism. The increased oxidative stress is one of the main factors in the etiology and complications of Diabetes Mellitus. Three of the GST (glutathione-S-transferase) genes, GSTM1, GSTT1 and GSTP1 have been found to have functional polymorphisms that are frequently present in the general population. GSTM1 and GSTT1 polymorphisms are the most common polymorphisms of GST enzymes in the human population with major ethnic differences. In our study, among two xenobiotic genetic variants GSTT1 and GSTM1, no association of GSTT1 was found, but the variant GSTM1 was found to be risk in Type 2 Diabetes Mellitus.

Keywords: Xenobiotics, GST genes, Type 2 Diabetes Mellitus.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW APRIL ISSUE PUBLISHED

    APRIL 2019 Issue has been successfully launched on 1 April 2019

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT