Abstract
THE ANTIBACTERIAL ACTIVITY OF THE METHANOLIC CRUDE EXTRACT FROM THE FRUIT OF PYRUS COMMUNIS (PEAR) FAMILY NAME ROSACEAE

Nones M.A.*, Torres R., Virtusio G.C., Tobias H., Raymundo J.R., Lacanilao J.O., Andal M. MSPharm

ABSTRACT

Antimicrobial Resistance (AMR) among infectious diseases is a growing public health challenge and poses a global health crisis. AMR threatens the effectiveness of prophylaxis and medication therapy of current antibiotic agents against pathogenic microorganisms. This hampers the control of infectious diseases resulting to increase in health care cost and risk of spreading resistant microorganisms in the community. The alarmingly prevalent health threat of Antimicrobial Resistance alters the therapeutic aid of antibacterial agents against deadly infections. One of the safe ways to combat and prevent the exacerbation of such threat is to provide further alternative substances with prospection of being more effective and powerful antibacterial agents. Health care in ancient times included the use of leaves, flowers, stems, berries and roots of herbs for their therapeutic or medicinal value. According to Indian Ayurvedic Medicine, the fruit of Pear is known to possess a lot of therapeutic activities such as anti-inflammatory, anti-hyperlipidemic, anti-diarrheal and anti-bacterial property. The Pyrus Communis of family Rosaceae and genus Pyrus, is a species of pear native and is commonly known as “white china pearâ€Â that can be mainly found in Asian countries, its origin is in Western China and is distributed all over the world. Pear fruit was procured in Sampaloc, Manila and about 100 g of Pear fruit were weighed and macerated with 80% methanol for 48 hours, filtered and evaporated to incipient dryness. The methanolic crude extract of Pyrus Communis (Pear) was investigated for its antibacterial potential against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus epidermidis through bactericidal assay using agar well diffusion method. The methanolic crude extract of Pear showed minimum zone of inhibitions comparable to the standard, Cefepime, against the microorganisms.

Keywords: Cefepime, Pear, Antimicrobial Resistance, Antibacterial.


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