Abstract
CONTROLLED RELEASE OF CARVEDILOL FROM HYDROPHILIC POLYMER MATRICES

RangaPriya M*, Punitha B, Sasikala S, Shanmugapriya Dharshini M, Sindhuja L

ABSTRACT

Transdermal drug delivery system is being extensively investigated as a viable alternative to drug delivery with improved bioavailability. Transdermal drug delivery system can improve the therapeutic efficacy and safety of the drug because drug is delivered through the skin at a predetermined and controlled rate. The aim of the present investigation is to formulate Carvedilol loaded transdermal patches by solvent evaporation method using varying concentrations of hydrophilic polymers like ethyl cellulose and hydroxy propyl ethyl cellulose and to evaluate the feasibility of hydrophilic polymers in the formulation of TDDS. The Carvedilol transdermal patches were found to be uniform in their weight and thickness with low SD values. The moisture content of the prepared formulations was low, which could help the formulations remain stable and reduce brittleness during long term storage. Although the moisture uptake of the formulations was also low, this could protect the formulations from microbial contamination and reduce bulkiness. As the concentration of hydrophilic polymer was increased, the amount of drug release was increased. After dissolution experiment the film showed the presence of pores/channels indicating the drug release is diffusion controlled. The present study concludes that the successful formulation of Carvedilol loaded transdermal patches can be done by using ethyl cellulose and hydroxyl propyl methyl cellulose as polymers.

Keywords: Transdermal patches, Carvedilol, HPMC, Solvent casting.


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