Abstract
PHARMACOPEIAL STANDARD DEVELOPMENT, HPTLC. FINGERPRINTING AND PHYSICOCHEMICAL RESEARCH STUDIES OF UNANI ANTI-PARALYTIC DRUG MAJOON-E-SEER ALWI KHANI

*Pawan Kumar Sagar, Munawwar Husain Kazmi, Javed Inam Siddiqui, M. A. Rasheed N

ABSTRACT

Pharmacopeial Standard development, HPTLC. Fingerprinting and Physicochemical research studies of Unani Anti-paralytic drugs Majoon-e-Seer Alwi Khani a classical formulation used in the treatment of Falij (Paralysis) and Laqwa(Facial Paralysis) and other Neurological disorders. Three drug samples of this compound formulation were taken into the studies which prepared in the Pharmacy at CRIUM., Hyderabad(Under CCRUM. Ministry of AYUSH.) by employing authenticated standard methods. The quality control & quality assurance studies were conducted in accordance to the WHO., AOAC., IPC. and UPC., approved guidelines. During these studies the physicochemical data showed that the drug samples contained foreign matter %, w/w., moisture /LOD. %, w/w. (not more than-7.41). and ash contained %.,w/w.(not more than-1.59), acid in-soluble ash %.,w/w.( not more than-0.10), soluble extract in water %.,w/v. (not less than-65.06) and in alcohol %.,w/v., (not less than-5.62) pH (1% Aq. Solution-6.31), pH (10 % Aq. Solution-6.01),Reducing sugar (33.98), Non-reducing sugar (5.63) were assessed in Majoon-e-SeerAlwiKhani. HPTLC studies of aqueous and alcohol extracts of both drug samples showed various spots at 366nm and 254nm (UV. region),under exposed to Iodine vapours, derivatized with 5% Methanolic sulphuric acid obtained with equate, best separation using selected suitable solvent system of mobile phase. The quality control studies results revealed the absence of hazardous and toxic contamination from the drug sample. Moreover the obtained research studies data and comparative screening will provide the referential supportive information in the development of pharmacopeial standard monographs and identification, reinvestigation, quality assurance and pharmacovigilance of the drug.

Keywords: Majoon-e-Seer Alwi Khani, Anti-paralytic, development of pharmacopeial standards, physicochemical, comparative screening, quality control and quality assurance.


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