Abstract
A PROSPECTIVE STUDY OF ADVERSE CUTANEOUS DRUG REACTIONS IN PEDIATRIC PATIENTS

Dr. Vimmi Agrawal*, Dr. Balvir Singh, Dr. S. P. Pandey

ABSTRACT

Adverse cutaneous drug reactions (ACDR) are the commonly reported type of ADR in pediatric age group and vary from milder forms to more severe types and can be important not only for further therapeutic strategy but also for future of the child. clinical patterns and the drugs causing various reactions are changing every year due to the emergence of newer molecules and changing trends in the use of drugs. Aims: Our objective was to evaluate the clinical pattern and the morphology of various cutaneous adverse drug reactions and their causality, severity and potential risk factors. Methods: fifty five patients with adverse cutaneous drug reactions were recruited for this study during 2013-2014. Results: clinical spectrum of ACDRs ranging from mild maculopapular rash to serious SJS/TEN was observed in age group of 0-10 years with male preponderance. Most of the reaction were mild to moderate in nature and could be managed by supportive treatment and withdrawal of culprit drug. Only 12.72% reaction was of severe grade that required hospitalization. Approximately 23.63% of ACDRs reported in this study were preventable. Polypharmacy was the most common predisposing factor observed in our study. Conclusion: implementing the ADRs reporting and monitoring system, one can promote drug safety and better patient care, among health care professionals.

Keywords: Adverse cutaneous drug reaction, adverse drug reaction, children.


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